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AI Summary: This is a policy document, specifically an Executive Order issued by the President of the United States focused on using artificial intelligence (AI) to advance pediatric cancer research and treatment. This regulation establishes a comprehensive approach to leveraging AI in pediatric cancer research through the Make America Healthy Again (MAHA) Commission. The order directs federal agencies to develop innovative AI-driven solutions for pediatric cancer by improving data infrastructure, enhancing data analysis of biological systems, and improving clinical trial design. The regulation builds upon the existing Childhood Cancer Data Initiative (CCDI), which was established in 2019 with $50 million in annual funding. Key actions include consolidating data from multiple sources, utilizing AI to select clinical trial participants, developing predictive modeling of disease progression and treatment outcomes, and creating new diagnostic and prognostic tools. The order also emphasizes increasing investment in pediatric cancer research, encouraging private sector engagement, and improving data sharing while maintaining patient privacy. The MAHA Commission, in coordination with various federal agencies, will lead efforts to implement these objectives, with a focus on using advanced technologies to unlock potential cures and improve pediatric cancer research and care infrastructure.