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AI Summary: This regulation establishes the Genesis Mission, a national effort to accelerate scientific discovery and technological innovation using artificial intelligence (AI). The mission will be led by the Department of Energy (DOE) and overseen by the Assistant to the President for Science and Technology. It aims to create an integrated American Science and Security Platform that will provide high-performance computing resources, AI modeling frameworks, computational tools, domain-specific AI models, secure data access, and experimental tools across key scientific domains including advanced manufacturing, biotechnology, critical materials, nuclear energy, quantum science, and semiconductors. The Secretary of Energy will identify at least 20 national science and technology challenges, develop partnerships with external research institutions and private sector partners, and establish mechanisms for collaboration while maintaining strict security protocols. The mission will involve coordinating across federal agencies, launching funding opportunities, creating research fellowship programs, and submitting annual reports on progress, research outcomes, and technological advances. The ultimate goal is to enhance America's technological leadership, strengthen national security, and accelerate scientific breakthroughs through AI-enabled research and innovation.