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AI Summary: This regulation (Executive Order 14303) establishes a "Gold Standard Science" framework for federal agencies to improve scientific integrity and restore public trust in scientific research and decision-making. The order requires agencies to conduct scientific activities that are reproducible, transparent, communicative about errors and uncertainties, collaborative, skeptical, structured for falsifiability, subject to unbiased peer review, accepting of negative results, and free from conflicts of interest. It mandates that agencies make scientific data publicly available, transparently acknowledge uncertainties, use a "weight of scientific evidence" approach, and communicate scientific information accurately. The order also requires agency heads to update their scientific integrity policies within 30 days, report on implementation, and ensure that scientific information used in decision-making is rigorous, impartial, and aligned with legal standards. Additionally, it provides interim guidance reverting to pre-January 2021 scientific integrity policies and requires agencies to review and potentially revise actions taken between January 2021 and January 2025 to ensure alignment with the new standards.