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AI Summary: This is a policy document - specifically an Executive Order withdrawing the United States from the World Health Organization (WHO). This regulation orders the United States' complete withdrawal from the World Health Organization, citing concerns about the organization's handling of the COVID-19 pandemic, perceived political influence, and funding inequities. The order directs the Secretary of State to immediately notify the United Nations and WHO leadership of the withdrawal, pauses all U.S. government funds and personnel transfers to the WHO, and halts negotiations on the WHO Pandemic Agreement and International Health Regulations amendments. The order revokes previous executive orders related to COVID-19 response and global health engagement, and instructs the National Security Council to establish new directorates to safeguard public health and biosecurity. The Assistant to the President for National Security Affairs is tasked with creating new coordination mechanisms, and the Director of the White House Office of Pandemic Preparedness and Response Policy is required to review and replace the 2024 U.S. Global Health Security Strategy. The document emphasizes that the withdrawal is due to perceived failures in the WHO's global health management and seeks to redirect U.S. health security efforts through alternative, more "credible and transparent" partners.