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AI Summary: This is a policy document - specifically an Executive Order establishing new guidelines and oversight mechanisms for federal grant-making processes. This regulation creates comprehensive new requirements for federal agencies regarding the awarding and management of discretionary grants. It establishes that each agency must designate a senior appointee to review funding opportunity announcements and grants to ensure they align with national interests and agency priorities. The order mandates that grants must demonstrably advance presidential policy priorities, cannot fund initiatives involving racial discrimination, must respect biological sex, cannot support illegal immigration, and must promote American values. The regulation introduces principles for grant selection, including preferring institutions with lower administrative costs, diversifying grant recipients, and prioritizing research with clear success benchmarks. The order also requires agencies to review and potentially modify existing grant terms to allow easier termination of grants that no longer serve agency or national interests. Additionally, it instructs the Office of Management and Budget to revise guidance to streamline application requirements and limit administrative overhead costs. The overall goal is to increase accountability, reduce wasteful spending, and ensure federal grants more directly serve American interests and produce meaningful results.